Description

5'-o-Tosylguanosine is a key nucleoside derivative where the 5'-hydroxyl group is protected by a tosyl moiety. This modification is critical for controlling reactivity in synthetic pathways, making it a valuable building block for pharmaceutical and biochemical research. It is primarily utilized by researchers and manufacturers in the fields of oligonucleotide synthesis, antiviral drug development, and as a precursor for more complex nucleoside analogs. Our supply ensures high purity and batch-to-batch consistency for reliable experimental and production outcomes.

Application

• Oligonucleotide Synthesis: Serves as a protected intermediate in the solid-phase and solution-phase synthesis of DNA and RNA sequences.
• Antiviral Prodrug Development: Used as a precursor in the research and synthesis of nucleoside-based antiviral agents.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies involving kinases, polymerases, and other nucleoside-processing enzymes.
• Pharmaceutical Intermediates: A crucial building block for creating modified nucleosides with potential therapeutic applications.
• Labeled Compound Synthesis: Facilitates the introduction of isotopic labels (e.g., deuterium, carbon-13) for metabolic and pharmacokinetic studies.

Basic Information

Product Name	5'-o-Tosylguanosine
CAS No.	39947-33-6
Molecular Formula	C17H19N5O7S
Molecular Weight	437.43 g/mol
Synonyms	Guanosine, 5'-O-(4-methylbenzenesulfonate); 5'-O-Tosylguanosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[[(4-methylphenyl)sulfonyl]oxy]methyl]oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 5'-O-(p-Toluenesulfonyl)guanosine; Guanosine 5'-(4-methylbenzenesulfonate); Tosylguanosine; p-Toluenesulfonylguanosine
EINECS	Contact for details

Quality Control

Our 5'-o-Tosylguanosine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to compliance with relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.