Description

o-tert-Butylhydroxylamine Hydrochloride is a versatile organic salt widely used as a key building block and reagent in advanced chemical synthesis. Its primary value lies in its role as a protected hydroxylamine derivative, enabling controlled introduction of the N-O functional group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of heterocycles, oximes, and as a chain terminator in polymerization processes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of various active pharmaceutical ingredients (APIs), including those with oxime ether or hydroxamic acid functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require the incorporation of a hydroxylamine moiety.
• Polymerization Modifier: Acts as a chain transfer agent or terminator in controlled radical polymerization processes to regulate polymer molecular weight.
• Organic Synthesis Reagent: Employed in the preparation of nitrones, isoxazolines, and other nitrogen-oxygen heterocycles for research and development.
• Crosslinking Agent: Utilized in the formulation of specialty resins, coatings, and adhesives where it can participate in crosslinking reactions.
• Bioconjugation Chemistry: Serves as a reagent for modifying biomolecules, such as proteins or peptides, through oxime ligation strategies.

Basic Information

Product Name	o-tert-Butylhydroxylamine Hydrochloride
CAS No.	39684-28-1
Molecular Formula	C4H12ClNO
Molecular Weight	125.60 g/mol
Synonyms	N-(tert-Butyl)hydroxylamine hydrochloride; 2-Methyl-2-propanylhydroxylamine hydrochloride; tert-Butylhydroxylamine HCl; N-tert-Butylhydroxylamine hydrochloride; 2-Amino-2-methylpropan-2-ol hydrochloride (tautomer); OTBA HCl; t-BuONH2·HCl; N-(1,1-Dimethylethyl)hydroxylamine hydrochloride
EINECS	Contact for details

Quality Control

Our o-tert-Butylhydroxylamine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158°C - 165°C
Loss on Drying	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.