Description

2,2-Difluoro-2-Phenylethanamine Hcl is a high-purity fluorinated amine hydrochloride salt, a key building block in advanced organic synthesis. This compound matters for its unique structural motif, combining a phenyl ring with a gem-difluoroethylamine group, which is valuable for modulating the physicochemical and metabolic properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of new drug candidates, especially in areas targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Peptidomimetics and Bioisosteres: The difluoroethylamine moiety acts as a bioisostere for amide or other functional groups, used in designing peptide analogs with improved stability and bioavailability.
• Material Science Research: Employed in the synthesis of specialty polymers, resins, or organic electronic materials that require fluorinated aromatic amines.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2,2-Difluoro-2-Phenylethanamine Hcl
CAS No.	39625-10-0
Molecular Formula	C8H10ClF2N
Molecular Weight	193.62 g/mol
Synonyms	2,2-Difluoro-2-phenylethanamine hydrochloride; α,α-Difluoro-β-phenylethylamine hydrochloride; 1-Phenyl-2,2-difluoroethanamine hydrochloride; (2,2-Difluoro-2-phenylethyl)amine hydrochloride; Benzeneethanamine, 2,2-difluoro-, hydrochloride; DFPEA·HCl; 39625-10-0; Phenylethanamine, 2,2-difluoro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-Phenylethanamine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.