Description

2-[(2S,3S)-2-[[(Benzyloxy)Carbonyl]Amino]3-Methyl-1-Oxopentyl]Hydrazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated, enantiomerically pure building block of significant value in advanced organic synthesis. This compound is engineered to provide a protected hydrazine moiety and a chiral amino acid derivative, enabling precise and efficient construction of complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly for peptide and peptidomimetic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce specific amino acid sequences with defined stereochemistry.
• Protease Inhibitor Development: Serves as a crucial component in the design and synthesis of protease inhibitors due to its hydrazide functionality.
• Chemical Biology Research: Employed in the synthesis of probes and tools for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in catalytic and stoichiometric asymmetric transformations.
• Custom Synthesis Projects: A starting material for contract research organizations (CROs) and CDMOs working on custom synthesis for clients.

Basic Information

Product Name	2-[(2S,3S)-2-[[(Benzyloxy)Carbonyl]Amino]3-Methyl-1-Oxopentyl]Hydrazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	39570-60-0
Molecular Formula	C19H29N3O5
Molecular Weight	379.45 g/mol
Synonyms	Boc-Hydrazide, L-Isoleucine Derivative; (2S,3S)-2-[[(Benzyloxy)carbonyl]amino]-3-methylpentanoic acid 2-[(1,1-dimethylethoxy)carbonyl]hydrazide; Nα-Cbz-Nδ-Boc-L-isoleucine hydrazide; tert-Butyl (2S,3S)-2-[(benzyloxycarbonyl)amino]-3-methyl-1-oxopentyl]carbazate; Z-Ile-NHNHBoc; CBZ-Ile-NHNHBOC; N-Carbobenzoxy-L-isoleucine hydrazide N'-tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our production of this high-purity building block adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) are provided with each shipment, detailing critical parameters such as chiral purity, chemical purity, and impurity profiles. While produced under GMP-like conditions suitable for pharmaceutical research, specifications can be customized to meet specific project requirements, including compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.