Description

(1R,8Aα,9S)-1,4,5,5A,6,7,8,8A-Octahydro-5Aα-Methyl-6-Methylene-9-Isopropyl-1,4α-Methano-2H-Cyclopent[D]Oxepine-2,5-Dione is a complex, high-purity bicyclic lactone compound of significant interest in advanced organic synthesis. Its intricate fused-ring structure makes it a valuable chiral building block and key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific stereochemistry and molecular complexity into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a sophisticated chiral scaffold for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex molecular architectures.
• Agrochemical Synthesis: Used as a key intermediate in the research and development of advanced pesticides and herbicides with specific stereochemical activity.
• Fine Chemical Production: Acts as a premium building block for creating specialty chemicals, flavors, fragrances, and advanced materials where precise stereochemistry is critical.
• Academic & Industrial Research: A valuable compound for methodological studies in organic chemistry, including catalysis, asymmetric synthesis, and natural product total synthesis.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for commercial production of high-value compounds.

Basic Information

Product Name	(1R,8Aα,9S)-1,4,5,5A,6,7,8,8A-Octahydro-5Aα-Methyl-6-Methylene-9-Isopropyl-1,4α-Methano-2H-Cyclopent[D]Oxepine-2,5-Dione
CAS No.	38750-01-5
Molecular Formula	C₁₅H₂₀O₃
Molecular Weight	248.32 g/mol
Synonyms	1,4α-Methano-2H-cyclopent[d]oxepine-2,5-dione, 1,4,5,5a,6,7,8,8a-octahydro-5a-methyl-6-methylene-9-(1-methylethyl)-, (1R,4aS,5aR,8aS,9R)-; (-)-α-Santonin; Santonin; Santoninum; Santonina; Laevogyrate Santonin; Santoninic Anhydride; Artemisinin-related intermediate.
EINECS	Contact for details

Quality Control

Our production of (1R,8Aα,9S)-1,4,5,5A,6,7,8,8A-Octahydro-5Aα-Methyl-6-Methylene-9-Isopropyl-1,4α-Methano-2H-Cyclopent[D]Oxepine-2,5-Dione adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.