Description

Benzo(A)Pyrene 4,5-Epoxide is a highly specific and reactive metabolite of the polycyclic aromatic hydrocarbon benzo[a]pyrene, a well-known environmental contaminant. This compound is of critical importance in toxicological and carcinogenicity research, serving as a key reference standard for analytical studies. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies engaged in metabolic pathway analysis, DNA adduct formation studies, and environmental health safety assessments.

Application

• Analytical Reference Standard: Primary use as a certified standard for the precise quantification of benzo[a]pyrene metabolites in complex matrices via HPLC, GC-MS, or LC-MS.
• Toxicological Research: Essential for in vitro and in vivo studies investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs) and their role in carcinogenesis.
• Biomarker Studies: Used in the development and validation of assays to detect and quantify specific DNA adducts formed by this epoxide, which are critical biomarkers of exposure and effect.
• Environmental Monitoring: Supports method development for tracking the metabolic fate of benzo[a]pyrene in environmental and biological samples, aiding in risk assessment.
• Pharmaceutical R&D: Employed in studies aimed at understanding drug-metabolizing enzyme interactions (e.g., cytochrome P450) and for screening potential chemopreventive agents.
• Regulatory Testing & Compliance: Serves as a critical component in method validation for laboratories adhering to regulatory guidelines from agencies like the EPA, FDA, and OECD.

Basic Information

Product Name	Benzo(A)Pyrene 4,5-Epoxide
CAS No.	37574-47-3
Molecular Formula	C20H12O
Molecular Weight	268.31 g/mol
Synonyms	Benzo[a]pyrene 4,5-oxide; 4,5-Epoxy-4,5-dihydrobenzo[a]pyrene; B[a]P 4,5-epoxide; BP 4,5-epoxide; Benzo(a)pyrene 4,5-oxide; 4,5-Epoxybenzo[a]pyrene; Benzo[def]chrysene 4,5-oxide
EINECS	Contact for details

Quality Control

Our Benzo(A)Pyrene 4,5-Epoxide is produced and handled under strict quality protocols to ensure the identity, purity, and stability required for sensitive research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided, documenting batch-specific data. We support compliance with GLP (Good Laboratory Practice) standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in DMSO, acetone; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.