Description

trans-Benzo[A]Pyrene-4,5-Dihydrodiol is a high-purity, well-defined metabolite of benzo[a]pyrene, a polycyclic aromatic hydrocarbon (PAH). This compound is of critical importance as a reference standard and a key intermediate in toxicological and metabolic research. It is primarily required by analytical laboratories, research institutions, and pharmaceutical companies engaged in environmental monitoring, carcinogenicity studies, and the investigation of PAH metabolic pathways.

Application

• Analytical Reference Standard: For the precise calibration and validation of HPLC, GC-MS, and LC-MS/MS systems in the quantification of PAH metabolites.
• Toxicology & Carcinogenicity Research: As a critical metabolite for studying the metabolic activation pathways of benzo[a]pyrene and its DNA-adduct forming potential.
• Biochemical Research: Used as a substrate in enzymatic studies involving cytochrome P450 and epoxide hydrolase activities.
• Environmental Monitoring: Serves as a biomarker standard for assessing human and ecological exposure to PAH contaminants.
• Pharmaceutical Development: Employed in early-stage research for screening compounds that may inhibit specific metabolic pathways linked to toxicity.

Basic Information

Product Name	trans-Benzo[A]Pyrene-4,5-Dihydrodiol
CAS No.	37571-88-3
Molecular Formula	C20H14O2
Molecular Weight	286.32 g/mol
Synonyms	trans-4,5-Dihydroxy-4,5-dihydrobenzo[a]pyrene; (±)-trans-4,5-Dihydrobenzo[a]pyrene-4,5-diol; Benzo[a]pyrene-4,5-dihydrodiol; BP-4,5-diol; 4,5-Dihydroxy-4,5-dihydrobenzo[a]pyrene; trans-BP-4,5-dihydrodiol; B[a]P-4,5-dihydrodiol
EINECS	Contact for details

Quality Control

Our trans-Benzo[A]Pyrene-4,5-Dihydrodiol is produced and handled under strict quality protocols to ensure batch-to-batch consistency and integrity for research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.