Description

4-Hydroxy-3-Iodobenzoic Acid is a halogenated benzoic acid derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and an iodine substituent, makes it a critical intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the life sciences, agrochemical, and material science sectors who require high-purity intermediates for coupling reactions and derivatization.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for thyroid hormone analogs and other iodinated bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators.
• Liquid Crystal & OLED Materials: Serves as a building block for creating iodinated aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science.
• Derivatization Agent: Used to introduce the hydroxy-iodo-benzoate moiety into larger molecular frameworks for property modulation.

Basic Information

Product Name	4-Hydroxy-3-Iodobenzoic Acid
CAS No.	37470-46-5
Molecular Formula	C7H5IO3
Molecular Weight	263.02 g/mol
Synonyms	3-Iodo-4-hydroxybenzoic acid; Benzoic acid, 4-hydroxy-3-iodo-; 4-Hydroxy-3-iodobenzoic acid; 3-Iodo-4-hydroxybenzoic acid; 4-Carboxy-2-iodophenol; 2-Iodo-4-carboxyphenol; 3-Iodosalicylic acid (common misnomer); 3-Iodo-4-hydroxy-benzoic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Iodobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.