Description

(1E)-3,3,3-Trifluoro-1-Nitroprop-1-Ene is a high-value fluorinated nitroalkene building block, prized for its unique reactivity profile in advanced organic synthesis. This compound is essential for introducing the trifluoromethyl and nitro functional groups in a single, versatile step, enabling the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and electronic materials, contributing to unique thermal, optical, and surface properties.
• Organic Synthesis Building Block: Employed in [4+2] cycloadditions, Michael additions, and other conjugate addition reactions to create complex, fluorinated heterocycles and aliphatic chains.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	(1E)-3,3,3-Trifluoro-1-Nitroprop-1-Ene
CAS No.	37468-00-1
Molecular Formula	C₃H₂F₃NO₂
Molecular Weight	141.05 g/mol
Synonyms	1-Nitro-3,3,3-trifluoropropene; (E)-3,3,3-Trifluoro-1-nitro-1-propene; 3,3,3-Trifluoro-1-nitroprop-1-ene; Trifluoronitropropene; TFP; (E)-1-Nitro-3,3,3-trifluoroprop-1-ene; 37468-00-1
EINECS	Contact for details

Quality Control

Our (1E)-3,3,3-Trifluoro-1-Nitroprop-1-Ene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality ensures reliable performance in your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Isomer Ratio (E/Z)	≥ 95:5 (E)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.