Description

α-Hydroxytriazolam is a significant pharmaceutical intermediate and metabolite of the benzodiazepine derivative triazolam. This compound is crucial for research and development in analytical chemistry, forensic science, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards and diagnostic kits.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of triazolam and its metabolites in drug testing and pharmacokinetic studies.
• Metabolite Research: Used in clinical and forensic research to study the metabolism, distribution, and excretion profile of triazolam.
• Analytical Method Development: Essential for developing and validating sensitive analytical methods, such as LC-MS/MS and HPLC, for benzodiazepine detection in biological matrices.
• Impurity Profiling: Employed in pharmaceutical quality control to identify and quantify process-related impurities or degradation products in triazolam API manufacturing.
• Biochemical Research: Acts as a tool compound in neuroscience and pharmacology research to investigate the structure-activity relationships (SAR) of benzodiazepine receptor ligands.
• Forensic Toxicology: A key analyte in forensic laboratories for confirming the presence of triazolam use in medico-legal cases.

Basic Information

Product Name	α-Hydroxytriazolam
CAS No.	37115-45-0
Molecular Formula	C17H12Cl2N4O
Molecular Weight	359.21 g/mol
Synonyms	α-Hydroxytriazolam; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol; 1-Methyl-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepin-4-ol; Triazolam Metabolite α-OH; Triazolam Hydroxy Metabolite; U-33030 Hydroxy Metabolite
EINECS	Contact for details

Quality Control

Our α-Hydroxytriazolam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for identification, and residual solvent analysis, to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific results for identity, purity, and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.