Description

(Is,2R)-D-N,n-Diethylnorephedrine HCl is a high-purity chiral amine derivative and a key pharmaceutical intermediate. This compound is valued for its specific stereochemistry, which is critical for producing active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development and synthesis of specialized drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of chiral APIs, particularly for central nervous system (CNS) agents and decongestants.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic compounds.
• Asymmetric Synthesis: Serves as a chiral auxiliary or resolving agent in stereoselective chemical reactions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in studies investigating adrenergic receptor interactions and related biochemical pathways.

Basic Information

Product Name	(Is,2R)-D-N,n-Diethylnorephedrine HCl
CAS No.	37025-58-4
Molecular Formula	C13H22ClNO
Molecular Weight	243.77 g/mol
Synonyms	D-N,N-Diethylnorephedrine hydrochloride; (1R,2S)-2-(Diethylamino)-1-phenylpropan-1-ol hydrochloride; (+)-N,N-Diethylnorephedrine HCl; (1R,2S)-N,N-Diethylnorpseudoephedrine hydrochloride; Cathine diethyl analogue HCl; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our (Is,2R)-D-N,n-Diethylnorephedrine HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.