Description

1,2-Diazaspiro[2.5]Oct-1-Ene-6-Carbonyl Chloride (9Ci) is a specialized spirocyclic organic building block featuring a reactive carbonyl chloride functional group. This compound is of significant value in advanced organic synthesis, serving as a key precursor for constructing complex nitrogen-containing heterocycles and pharmacophores. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel spirocyclic drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of new herbicides and insecticides with unique modes of action derived from its spirocyclic diaza structure.
• Ligand and Catalyst Development: Serves as a precursor for creating complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetic Research: Employed to introduce constrained, spirocyclic motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Material Science Precursor: Utilized in the synthesis of specialty polymers and organic electronic materials requiring rigid, heterocyclic components.
• Chemical Biology Probes: Acts as a reactive handle for labeling or cross-linking in the design of activity-based probes and bioconjugation reagents.

Basic Information

Item	Information
Product Name	1,2-Diazaspiro[2.5]Oct-1-Ene-6-Carbonyl Chloride (9Ci)
CAS No.	36908-78-8
Molecular Formula	C7H7ClN2O
Molecular Weight	170.60 g/mol
Synonyms	6-Carbonylchloride-1,2-diazaspiro[2.5]oct-1-ene; 1,2-Diazaspiro[2.5]oct-1-ene-6-carbonyl chloride; Spiro[cyclopropane-1,6'-[1,2]diazacyclohept-1'-ene]-8'-carbonyl chloride; 1-Aza-2-azaspiro[2.5]oct-1-ene-6-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1,2-Diazaspiro[2.5]Oct-1-Ene-6-Carbonyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), impurity profile, and moisture content are provided and available upon request. We adhere to cGMP principles for advanced pharmaceutical intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.