Description

Benzo(A)Pyrene 9,10-Oxide is a crucial reactive metabolite and reference standard derived from the polycyclic aromatic hydrocarbon benzo[a]pyrene. This compound is of significant importance for researchers investigating the mechanisms of chemical carcinogenesis and metabolic activation pathways. It serves as an essential analytical standard for laboratories in the environmental, toxicological, and pharmaceutical sectors, enabling precise quantification and study of PAH-derived reactive intermediates.

Application

• Toxicological Research: Used as a critical reference standard in studies of metabolic activation, DNA adduct formation, and the carcinogenic mechanisms of polycyclic aromatic hydrocarbons (PAHs).
• Environmental Analysis: Serves as a high-purity calibration standard for the detection and quantification of benzo[a]pyrene metabolites in environmental samples, soil, and air particulate matter.
• Biomarker Development: Employed in the development and validation of analytical methods (e.g., HPLC, GC-MS) for measuring specific DNA or protein adducts as biomarkers of PAH exposure.
• Pharmaceutical Safety Testing: Utilized in drug metabolism and pharmacokinetics (DMPK) studies to understand enzyme-mediated bioactivation and potential toxicities.
• Academic and Institutional Research: A key reagent for universities and research institutes focusing on chemical biology, molecular toxicology, and cancer research.
• Regulatory and Compliance Testing: Supports testing protocols for regulatory submissions and safety assessments of compounds that may form similar reactive epoxides.

Basic Information

Product Name	Benzo(A)Pyrene 9,10-Oxide
CAS No.	36504-66-2
Molecular Formula	C₂₀H₁₂O
Molecular Weight	268.31 g/mol
Synonyms	Benzo[a]pyrene 9,10-oxide; 9,10-Epoxy-9,10-dihydrobenzo[a]pyrene; BP 9,10-oxide; Benzo(a)pyrene 9,10-epoxide; 9,10-Dihydrobenzo[a]pyrene 9,10-oxide; B(a)P 9,10-oxide; 36504-66-2 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of Benzo(A)Pyrene 9,10-Oxide is produced and handled under strict quality protocols to ensure identity, purity, and stability for research applications. Our products undergo rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store desiccated at 2-8°C. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in DMSO, acetone; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.