Description

Benzo(A)Pyrene 7,8-Oxide is a critical reactive metabolite and intermediate in the study of polycyclic aromatic hydrocarbon (PAH) toxicology. This compound is essential for researchers investigating the mechanisms of carcinogenesis, DNA adduct formation, and metabolic activation pathways. It is primarily utilized by analytical laboratories, toxicology research institutions, and pharmaceutical companies engaged in metabolic studies and safety assessment of environmental contaminants.

Application

• Toxicological Research: Used as a standard and reference material in studies of PAH metabolic activation and DNA damage.
• Biochemical Studies: Employed to investigate enzyme kinetics, specifically the role of epoxide hydrolase and cytochrome P450 enzymes.
• Analytical Reference Standard: Serves as a high-purity calibrant in HPLC, GC-MS, and LC-MS methods for the quantification of PAH metabolites.
• Carcinogenicity Mechanism Studies: Fundamental for understanding the formation of benzo(a)pyrene diol epoxide, the ultimate carcinogen.
• Environmental Monitoring: Supports method development for detecting and quantifying reactive PAH intermediates in complex matrices.
• Pharmaceutical Safety Testing: Used in in vitro and in vivo models to assess genotoxicity and metabolic pathways.

Basic Information

Product Name	Benzo(A)Pyrene 7,8-Oxide
CAS No.	36504-65-1
Molecular Formula	C₂₀H₁₂O₂
Molecular Weight	284.31 g/mol
Synonyms	Benzo[a]pyrene 7,8-oxide; 7,8-Epoxy-7,8-dihydrobenzo[a]pyrene; BP 7,8-oxide; 7,8-Oxidebenzo[a]pyrene; Benzo(a)pyrene-7,8-epoxide; 7,8-Dihydrobenzo[a]pyrene 7,8-epoxide; B(a)P 7,8-oxide
EINECS	Contact for details

Quality Control

Every batch of Benzo(A)Pyrene 7,8-Oxide is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Solubility	Soluble in DMSO, acetone; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.