Description

β-D-Ribofuranose (9Ci) is a fundamental carbohydrate building block, specifically a pentose sugar in its furanose ring form. This compound is of significant value as a key chiral intermediate and precursor in the synthesis of nucleosides, nucleotides, and various bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing antiviral agents, mRNA therapeutics, and other nucleoside-based drugs.

Application

• Nucleoside & Nucleotide Synthesis: Serves as the critical sugar moiety for constructing ribonucleosides like adenosine, guanosine, cytidine, and uridine.
• Pharmaceutical Intermediates: A key starting material in the production of antiviral and anticancer prodrugs, including those for hepatitis C and HIV.
• mRNA Vaccine & Therapeutic Development: Used in research and process development for cap analogs and modified nucleosides to enhance mRNA stability and translation efficiency.
• Biochemical Research: Employed as a substrate or standard in enzymatic studies, metabolic pathway analysis, and glycoscience research.
• Fine Chemical Synthesis: Acts as a chiral pool synthon for the asymmetric synthesis of complex natural products and specialty chemicals.
• Diagnostic Reagents: Utilized in the formulation of kits and reagents for molecular biology and diagnostic assays.

Basic Information

Item	Details
Product Name	β-D-Ribofuranose (9Ci)
CAS No.	36468-53-8
Molecular Formula	C5H10O5
Molecular Weight	150.13 g/mol
Synonyms	D-Ribofuranose; β-D-Ribofuranose; Ribose (cyclic form); D-(-)-Ribose; D-Ribose, cyclic; 9CI; Aldehydo-D-ribose; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal cyclic form
EINECS	Contact for details

Quality Control

Our β-D-Ribofuranose is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, optical rotation measurement, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.