Description

6-Monoacetylmorphine Hydrochloride is a specific hydrochloride salt of a key morphine metabolite, offering a standardized reference material for analytical and research purposes. Its primary value lies in providing a reliable and well-characterized standard essential for accurate identification and quantification in forensic, clinical, and pharmaceutical testing. This compound is critically needed by analytical laboratories, forensic science institutions, and pharmaceutical R&D departments involved in drug metabolism studies, toxicology screening, and quality control of related substances.

Application

• Forensic Toxicology Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of 6-acetylmorphine, a definitive marker for heroin use, in biological samples like urine, blood, and hair.
• Clinical Laboratory Testing: Serves as a critical calibrant and control in diagnostic assays and LC-MS/MS methods to monitor drug abuse and compliance in pain management.
• Pharmaceutical Impurity Profiling: Employed in the analysis and control of potential impurities or degradation products in morphine and semi-synthetic opioid drug substances and products.
• Metabolite Research: Utilized in pharmacokinetic and metabolic pathway studies to understand the biotransformation of heroin and related opioids.
• Method Development & Validation: Essential for developing, optimizing, and validating new analytical methods in compliance with guidelines from agencies like the FDA and EMA.
• Quality Control & Assurance: Acts as a system suitability standard and a component of proficiency testing programs within analytical and forensic laboratories.

Basic Information

Product Name	6-Monoacetylmorphine Hydrochloride
CAS No.	36418-22-1
Molecular Formula	C19H21NO4 • HCl
Molecular Weight	363.83 g/mol (Free base: 327.37)
Synonyms	6-Acetylmorphine Hydrochloride; 6-MAM HCl; 6-Monoacetylmorphine HCl; Heroin Metabolite Hydrochloride; (5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol 6-acetate hydrochloride; 3,6-Diacetylmorphine Impurity; 6-O-Acetylmorphine Hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Monoacetylmorphine Hydrochloride is manufactured and handled under strict quality systems suitable for reference standard applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) are provided, detailing the results against stringent internal specifications. We support compliance needs for laboratories operating under GLP or ISO 17025.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.