Description

8-Fluoro-4-hydroxyquinoline-2-carboxylic acid is a high-purity, fluorinated quinoline derivative serving as a critical advanced intermediate in modern organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate its unique fluorinated quinoline scaffold.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in antimicrobial and anticancer research where the quinoline core is prevalent.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the fluorinated quinoline structure.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Complex Ligand Preparation: Utilized in the synthesis of specialized chelating agents or ligands for catalytic systems due to its carboxylic acid and heterocyclic nitrogen functionalities.
• Fluorinated Compound Libraries: An essential starting material for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors or fluorescent markers owing to the conjugated quinoline system.

Basic Information

Product Name	8-Fluoro-4-hydroxyquinoline-2-carboxylic acid
CAS No.	36308-79-9
Molecular Formula	C10H6FNO3
Molecular Weight	207.16 g/mol
Synonyms	8-Fluoro-4-hydroxy-2-quinolinecarboxylic acid; 8-Fluoro-4-hydroxyquinoline-2-carboxylic Acid; 2-Quinolinecarboxylic acid, 8-fluoro-4-hydroxy-; 8-Fluoro-4-hydroxy-2-quinolinecarboxylic acid; 8-Fluoro-4-hydroxyquinoline-2-carboxylate; 8-F-4-OH-Q-2-COOH; 36308-79-9 (CAS)
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4-hydroxyquinoline-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.