Description

o-Mesitylenesulfonylhydroxylamine (MSH or AMS) is a versatile and highly reactive aminating agent used to introduce amino groups into organic molecules. This compound is particularly valued for its role as a source of electrophilic nitrogen in the synthesis of complex heterocycles and pharmaceuticals. It is an essential reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient and selective amination pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the electrophilic amination of carbanions, enolates, and organometallic compounds in API development.
• Heterocyclic Chemistry: Facilitates the construction of nitrogen-containing rings such as aziridines, which are crucial scaffolds in medicinal chemistry.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific amine functionalities.
• Polymer Modification: Employed to introduce amino groups into polymer backbones, altering material properties for specialty coatings or adhesives.
• Bioconjugation & Labeling: Useful in biochemical research for modifying proteins, peptides, or other biomolecules with amine-reactive tags.
• Catalyst & Ligand Development: Serves as a building block for creating novel nitrogen-donor ligands used in transition metal catalysis.

Basic Information

Product Name	o-Mesitylenesulfonylhydroxylamine
CAS No.	36016-40-7
Molecular Formula	C9H13NO3S
Molecular Weight	215.27 g/mol
Synonyms	AMS; Mesitylenesulfonylhydroxylamine; 2,4,6-Trimethylbenzenesulfonylhydroxylamine; o-Mesitylenesulfonhydroxamic acid; MSH; (2,4,6-Trimethylphenyl)sulfonylhydroxylamine; N-Hydroxy-2,4,6-trimethylbenzenesulfonamide; Electrophilic Aminating Agent MSH
EINECS	Contact for details

Quality Control

Our o-Mesitylenesulfonylhydroxylamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), moisture content (KF), and related substances is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent decomposition. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.