Description

n-Boc-L-Arginine Hydrochloride is a protected derivative of the essential amino acid L-arginine, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for pharmaceutical and biotechnological applications. It is primarily utilized by the pharmaceutical industry for the development of peptide-based drugs, APIs, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of complex peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Linker Chemistry: Used in the preparation of antibody-drug conjugates (ADCs) and other bioconjugates where a protected guanidino group is required.
• Research & Development: An essential reagent in academic and industrial R&D for studying peptide structure, function, and for novel drug discovery.
• Custom Peptide Production: Employed by CROs and CDMOs for the reliable and scalable manufacture of custom peptides for clients.

Basic Information

Product Name	n-Boc-L-Arginine Hydrochloride
CAS No.	35897-34-8
Molecular Formula	C11H23N5O4 • HCl
Molecular Weight	321.79 g/mol (Free base: 286.33)
Synonyms	Boc-Arg-OH • HCl; Nα-Boc-Nω-nitro-L-arginine hydrochloride (common misnomer); Nα-tert-Butyloxycarbonyl-L-arginine hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)-5-guanidinopentanoic acid hydrochloride; Boc-L-Arg(HCl)-OH; Boc-Arg(HCl)-OH; L-Arginine, N2-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1); tert-Butyloxycarbonyl-L-arginine hydrochloride
EINECS	Contact for details

Quality Control

Our n-Boc-L-Arginine Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	+15.0° to +18.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.