Description

2,8-Bis(Trifluoromethyl)-4-Quinolinol is a specialized fluorinated quinoline derivative, a high-value building block prized for its unique electronic and steric properties imparted by the trifluoromethyl groups. This compound is critical for researchers and manufacturers developing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and bioactivity are required. It serves as a key intermediate in pharmaceutical research, agrochemical synthesis, and the development of functional materials for the electronics industry.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms contribute to improved metabolic stability and membrane permeability.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers, liquid crystals, and organic light-emitting diodes (OLEDs) due to its electron-withdrawing characteristics.
• Coordination Chemistry & Catalysis: Acts as a ligand for metal complexes used in catalytic processes, leveraging the quinolinol structure for metal chelation.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and other transformations to introduce the bis(trifluoromethyl)quinoline moiety into more complex molecular architectures.

Basic Information

Product Name	2,8-Bis(Trifluoromethyl)-4-Quinolinol
CAS No.	35853-41-9
Molecular Formula	C₁₁H₅F₆NO
Molecular Weight	281.16 g/mol
Synonyms	4-Hydroxy-2,8-bis(trifluoromethyl)quinoline; 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline; 4-Quinolinol, 2,8-bis(trifluoromethyl)-; 2,8-Bis(trifluoromethyl)quinolin-4-ol; HQ-BTFM
EINECS	Contact for details

Quality Control

Every batch of 2,8-Bis(Trifluoromethyl)-4-Quinolinol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.