Description

Fmoc-Hydrazide Hcl CAS NO 35661-51-9 is a high-purity, protected hydrazine derivative widely used as a key building block in organic synthesis and peptide chemistry. Its primary value lies in its role as a versatile reagent for the introduction of the hydrazide functional group under Fmoc-protection strategies, enabling the synthesis of complex molecules with high selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries, particularly for developing peptide-based therapeutics, creating specialized linkers, and synthesizing heterocyclic compounds.

Application

• Peptide Synthesis: A crucial reagent for the solid-phase and solution-phase synthesis of peptide hydrazides and peptide fragments, facilitating native chemical ligation.
• Pharmaceutical Intermediates: Serves as a key building block in the production of active pharmaceutical ingredients (APIs), especially for cancer therapeutics and hormone analogs.
• Bioconjugation & Linker Chemistry: Used to create cleavable linkers and functionalize biomolecules for drug delivery systems, diagnostics, and proteomics research.
• Heterocycle Formation: Employed in the synthesis of various nitrogen-containing heterocycles, such as pyrazoles and triazoles, which are common scaffolds in medicinal chemistry.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialized polymers and functional materials.
• Chemical Biology Probes: Utilized for labeling and modifying proteins and other biomolecules to study biological pathways and interactions.

Basic Information

Item	Details
Product Name	Fmoc-Hydrazide Hcl
CAS No.	35661-51-9
Molecular Formula	C₁₅H₁₅N₂O₂·HCl
Molecular Weight	300.75 g/mol
Synonyms	Fmoc-hydrazine hydrochloride; N-(9-Fluorenylmethoxycarbonyl)hydrazine hydrochloride; 9-Fluorenylmethyl carbazate hydrochloride; Fmoc-NHNH₂·HCl; (9H-Fluoren-9-yl)methyl carbazate hydrochloride; N-Fmoc-hydrazine HCl; FMOC-HYDRAZINE HYDROCHLORIDE; 9-Fluorenylmethoxycarbonyl hydrazine HCl
EINECS	Contact for details

Quality Control

Our Fmoc-Hydrazide Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.