Description

(-)-2,3-o-Benzylidene-L-Threitol is a chiral, protected derivative of L-threitol, a valuable building block in organic synthesis. This compound matters as a key intermediate for the preparation of complex molecules, particularly in pharmaceutical research and asymmetric catalysis. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing chiral ligands and active pharmaceutical ingredients (APIs).

Application

• Chiral Ligand Synthesis: A crucial precursor for synthesizing enantiomerically pure phosphine, phosphite, and other donor ligands used in asymmetric hydrogenation and other catalytic reactions.
• Pharmaceutical Intermediates: Serves as a protected chiral diol scaffold in the multi-step synthesis of complex drug candidates, especially those targeting infectious diseases and metabolic disorders.
• Natural Product Synthesis: Used in the stereocontrolled construction of sugar analogs and other natural products that contain the threitol backbone.
• Agrochemical Research: Employed in developing chiral active ingredients for herbicides and fungicides where specific stereochemistry is critical for activity.
• Material Science: Potential monomer or cross-linker for creating chiral polymers with specific optical or mechanical properties.
• Analytical Standards: Used as a reference standard in chromatographic methods (HPLC, GC) for quality control and method development in chiral analysis.

Basic Information

Product Name	(-)-2,3-o-Benzylidene-L-Threitol
CAS No.	35572-34-0
Molecular Formula	C11H14O4
Molecular Weight	210.23 g/mol
Synonyms	(2R,3R)-2,3-O-Benzylidene-1,4-butanediol; L-Threitol 2,3-O-benzylidene acetal; (2R,3R)-2,3-O-(Phenylmethylene)-1,2,3,4-butanetetrol; (-)-2,3-O-Benzylidene-L-threitol; (2R,3R)-2,3-O-Benzylidene-threitol; Benzylidene-L-threitol; L-Threitol benzylidene acetal
EINECS	Contact for details

Quality Control

Our (-)-2,3-o-Benzylidene-L-Threitol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.