Description

trans-(-)-1,2-Cyclohexanediamine Dihydrochloride is a high-purity, chiral diamine salt widely used as a critical building block and ligand in asymmetric synthesis. This compound matters for its role in creating enantiomerically pure pharmaceuticals and fine chemicals, where its stereochemistry is essential for biological activity and process selectivity. It is needed by research institutions, pharmaceutical development labs, and manufacturers of advanced catalysts and agrochemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and cardiovascular drugs.
• Asymmetric Catalysis: Serves as a versatile ligand for transition metal catalysts (e.g., with ruthenium, rhodium) in enantioselective hydrogenation and other C-C bond-forming reactions.
• Chiral Resolution Agent: Used to separate enantiomers of racemic carboxylic acids via diastereomeric salt formation.
• Polymer Chemistry: Employed in the production of specialty polyamides and epoxy curing agents where stereoregularity impacts material properties.
• Agrochemical Synthesis: A building block for chiral herbicides, fungicides, and plant growth regulators.
• Research & Development: Essential for academic and industrial R&D in organic and medicinal chemistry for exploring new synthetic methodologies.

Basic Information

Product Name	trans-(-)-1,2-Cyclohexanediamine Dihydrochloride
CAS No.	35018-63-4
Molecular Formula	C6H14N2·2HCl
Molecular Weight	195.11 g/mol
Synonyms	(1R,2R)-(-)-1,2-Diaminocyclohexane Dihydrochloride; (1R,2R)-1,2-Cyclohexanediamine Dihydrochloride; trans-(1R,2R)-1,2-Diaminocyclohexane Dihydrochloride; (R,R)-1,2-Diaminocyclohexane Dihydrochloride; DACH·2HCl; (R,R)-DACH Dihydrochloride; (-)-trans-1,2-Diaminocyclohexane Dihydrochloride; (1R,2R)-(-)-1,2-Diaminocyclohexane Dihydrochloride
EINECS	Contact for details

Quality Control

Our trans-(-)-1,2-Cyclohexanediamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect purity and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Optical Rotation	-12.0° to -14.0° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.