Description

3-Hydroxy-3-Methylglutaric Anhydride is a versatile cyclic anhydride derivative of 3-hydroxy-3-methylglutaric acid, serving as a key chiral building block and reactive intermediate in advanced organic synthesis. Its value lies in its bifunctional reactivity, offering both anhydride and hydroxyl groups for selective modifications, which is critical for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of statin-class drugs, including HMG-CoA reductase inhibitors like Atorvastatin and Rosuvastatin.
• Fine Chemical Synthesis: Used as a building block for producing complex organic molecules, flavors, and fragrances requiring specific stereochemistry.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing specialty polyesters and polyanhydrides with tailored properties.
• Agrochemical Development: Employed in the research and production of advanced herbicides and plant growth regulators.
• Bioconjugation & Linker Chemistry: Utilized for modifying biomolecules, peptides, or creating cleavable linkers in prodrug design and bioconjugate vaccines.
• Academic & R&D: Serves as a standard and starting material in organic chemistry research for methodological development and studying reaction mechanisms.

Basic Information

Product Name	3-Hydroxy-3-Methylglutaric Anhydride
CAS No.	34695-32-4
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	3-Hydroxy-3-methylglutaric anhydride; 3-Hydroxy-3-methylpentanedioic anhydride; HMGA; (3-Hydroxy-3-methyl-1,5-dioxolan-4-one); 3-Methyl-3-hydroxyglutaric anhydride; 3-Hydroxy-3-methyl-glutaric acid cyclic anhydride; 3-Hydroxy-3-methylglutaric acid anhydride; 3-Hydroxy-3-methylpentanedioic acid cyclic anhydride
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methylglutaric Anhydride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, identity confirmation by IR and NMR spectroscopy, and precise quantification of assay and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all critical parameters to ensure the material meets your specific research or cGMP-grade requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or storing under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.