Description

n-[(Phenylmethoxy)Carbonyl]-2-(tert-Butoxycarbonyl)-L-Threonine Hydrazide is a sophisticated, high-purity protected amino acid derivative essential for advanced organic synthesis. This compound matters as a critical building block for the controlled assembly of complex peptides and peptidomimetics, offering orthogonal protection strategies for the threonine side chain and backbone. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic peptides, active pharmaceutical ingredients (APIs), and specialized biochemical probes where precise molecular architecture is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential incorporation of L-threonine into peptide chains, particularly where side-chain hydroxyl protection is required.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex, long-chain peptides or cyclic peptides in solution, leveraging its hydrazide functionality for segment condensation strategies.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based drugs, hormone analogs, and targeted biologics.
• Bioconjugation and Probe Development: The reactive hydrazide group enables site-specific conjugation to aldehydes or ketones, useful for creating labeled peptides, antibody-drug conjugates (ADCs), or diagnostic agents.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and peptide science, exploring new coupling methodologies or protection group strategies.

Basic Information

Product Name	n-[(Phenylmethoxy)Carbonyl]-2-(tert-Butoxycarbonyl)-L-Threonine Hydrazide
CAS No.	34670-11-6
Molecular Formula	C17H25N3O6
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-Thr(Boc)-NHNH2; Nα-Fmoc-Nγ-Boc-L-threonine hydrazide; Fmoc-L-threonine(Boc)-hydrazide; (2S,3R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxycarbonyloxy]-butanoic acid hydrazide; Boc-Thr(Fmoc)-NHNH2; L-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[(1,1-dimethylethoxy)carbonyl]-, hydrazide; Fmoc-Thr(tBuOCO)-NHNH2
EINECS	Contact for details

Quality Control

Our n-[(Phenylmethoxy)Carbonyl]-2-(tert-Butoxycarbonyl)-L-Threonine Hydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical research. Products undergo rigorous analytical testing, including HPLC for purity assessment, chiral analysis to confirm stereochemical integrity, and comprehensive identity confirmation. A detailed Certificate of Analysis (COA) is provided with each batch, documenting key parameters such as assay, chiral purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent exposure to atmospheric moisture, which can affect purity and reactivity. For optimal performance, allow the sealed container to equilibrate to room temperature before opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.