Description

3-Hydroxy-2-Methoxytetrahydrofuran is a versatile chiral building block and protected glycolaldehyde equivalent, widely utilized in fine chemical synthesis. This compound is valued for its ability to introduce functionalized tetrahydrofuran moieties, which are key structural motifs in pharmaceuticals and agrochemicals. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in asymmetric synthesis and the development of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of antiviral agents, antibiotics, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Fine Chemical Production: Serves as a protected form of glycolaldehyde in multi-step organic syntheses for flavors, fragrances, and specialty polymers.
• Academic & R&D: A valuable reagent in medicinal chemistry and process development for exploring new synthetic routes.
• Nucleoside & Carbohydrate Chemistry: Employed in the synthesis of modified nucleosides and complex sugar derivatives.

Basic Information

Product Name	3-Hydroxy-2-Methoxytetrahydrofuran
CAS No.	33691-67-7
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	2-Methoxy-3-hydroxytetrahydrofuran; 3-Hydroxy-2-methoxyoxolane; Tetrahydro-3-hydroxy-2-methoxyfuran; 2-Methoxy-3-tetrahydrofuranol; Glycolaldehyde dimethyl acetal, cyclic; (3R)-3-Hydroxy-2-methoxytetrahydrofuran (for enantiomer); (3S)-3-Hydroxy-2-methoxytetrahydrofuran (for enantiomer)
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-2-Methoxytetrahydrofuran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, ensuring full traceability and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged storage or when working with large quantities to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.