Description

4-(2,3-Dihydroxypropylamino)-2-(5-Nitro-2-Thienyl)-Quinazoline is a specialized quinazoline derivative, a high-value chemical intermediate designed for advanced synthesis. Its molecular structure, featuring a nitro-thienyl group and a dihydroxypropylamino side chain, makes it a critical building block for research and development in targeted therapeutic areas. This compound is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Key intermediate in the research and synthesis of novel pharmaceutical compounds, particularly in oncology and targeted therapy.
• Building block for the development of kinase inhibitor candidates and other enzyme-targeting molecules.
• Precursor in medicinal chemistry for creating libraries of quinazoline-based derivatives for biological screening.
• Used in academic and industrial research programs investigating structure-activity relationships (SAR).
• Specialty intermediate for contract research organizations (CROs) and custom synthesis projects.

Basic Information

Product Name	4-(2,3-Dihydroxypropylamino)-2-(5-Nitro-2-Thienyl)-Quinazoline
CAS No.	33372-40-6
Molecular Formula	C₁₅H₁₆N₄O₄S
Molecular Weight	348.38 g/mol
Synonyms	2-(5-Nitro-2-thienyl)-4-[(2,3-dihydroxypropyl)amino]quinazoline; 4-[(2,3-Dihydroxypropyl)amino]-2-(5-nitro-2-thienyl)quinazoline; Quinazoline, 4-[(2,3-dihydroxypropyl)amino]-2-(5-nitro-2-thienyl)-; 4-(2,3-Dihydroxypropylamino)-2-(5-nitrothiophen-2-yl)quinazoline; 33372-40-6; 4-(2,3-Dihydroxypropylamino)-2-(5-nitro-2-thienyl)quinazoline
EINECS	Contact for details

Quality Control

Our 4-(2,3-Dihydroxypropylamino)-2-(5-Nitro-2-Thienyl)-Quinazoline is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.