Description

4-[(tert-Butoxycarbonylamino)Methyl]Benzoic Acid CAS NO 33233-67-9 is a high-purity, protected amino acid derivative widely used as a critical building block in organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for peptide synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing benzylamine or benzoic acid motifs.
• Peptide Synthesis: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis, where the Boc (tert-butoxycarbonyl) group provides orthogonal protection.
• Linker Chemistry: Utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates, where its carboxylic acid and protected amine functionalities allow for specific coupling strategies.
• Agrochemical Research: Employed as an intermediate in the design and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the synthesis of specialty polymers, dendrimers, and organic frameworks that require precise functional group incorporation.
• Chemical Biology Probes: Acts as a precursor for fluorescent tags, affinity labels, and other molecular probes used in biochemical research.

Basic Information

Product Name	4-[(tert-Butoxycarbonylamino)Methyl]Benzoic Acid
CAS No.	33233-67-9
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	4-[(Boc-amino)methyl]benzoic acid; 4-(Boc-aminomethyl)benzoic acid; 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid; 4-(N-Boc-aminomethyl)benzoic acid; 4-Carboxybenzylcarbamic acid tert-butyl ester; Benzoic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; Boc-4-aminomethylbenzoic acid; p-[(tert-Butoxycarbonylamino)methyl]benzoic acid
EINECS	Contact for details

Quality Control

Our 4-[(tert-Butoxycarbonylamino)Methyl]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.