Description

1,4:5,8-Dimethanonaphthalen-2(1H)-One, 3,4,4A,5,8,8A-Hexahydro-, (1Alp Ha,4Alpha,4Abeta,5Beta,8Beta,8Abeta)- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its rigid, polycyclic framework which serves as a versatile building block for the development of complex molecular architectures, including pharmaceuticals and specialty chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate unique structural motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, where its complex structure can contribute to unique modes of action.
• Ligand and Catalyst Development: Acts as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for high-performance polymers and resins with specific thermal or mechanical properties.
• Academic & Industrial R&D: Employed in methodological studies and total synthesis projects requiring sophisticated bicyclic systems.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals for electronics or optics applications.

Basic Information

Product Name	1,4:5,8-Dimethanonaphthalen-2(1H)-One, 3,4,4A,5,8,8A-Hexahydro-, (1Alp Ha,4Alpha,4Abeta,5Beta,8Beta,8Abeta)-
CAS No.	33163-94-9
Molecular Formula	C₁₂H₁₄O
Molecular Weight	174.24 g/mol
Synonyms	(1α,4α,4aβ,5β,8β,8aβ)-3,4,4a,5,8,8a-Hexahydro-1,4:5,8-dimethanonaphthalen-2(1H)-one; Hexahydro-1,4:5,8-dimethanonaphthalen-2(1H)-one; endo,endo-Bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic Anhydride derivative; Bicyclo[2.2.2]oct-5-ene-2,3-dicarboximide precursor; 33163-94-9; (1R,4R,4aS,5S,8S,8aS)-Octahydro-1,4:5,8-dimethanonaphthalene-2,3-dione (related structure).
EINECS	Contact for details

Quality Control

Our 1,4:5,8-Dimethanonaphthalen-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that include data from HPLC, GC, NMR, and chiral analysis. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture. For long-term storage, consider an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.