Description

1,3-Dioxolane-4-Methanol, 2,2,4-Trimethyl- is a specialized cyclic acetal derivative of glycerol, valued for its unique chemical structure that serves as a versatile building block and protective group in organic synthesis. This compound is particularly significant for its ability to introduce chiral centers and functionalized side chains into complex molecules. It is primarily sought by research and development chemists in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and the production of advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Asymmetric Synthesis: Used as a chiral auxiliary or a protected form of glycerol in stereoselective reactions to construct complex molecular architectures.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polymers with tailored properties like biodegradability or specific optical activity.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Fine Chemical Production: Acts as a precursor for fragrances, flavors, and other high-value specialty chemicals requiring specific stereochemistry.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry and material science research.

Basic Information

Product Name	1,3-Dioxolane-4-Methanol, 2,2,4-Trimethyl-
CAS No.	32379-10-5
Molecular Formula	C7H14O3
Molecular Weight	146.18 g/mol
Synonyms	2,2,4-Trimethyl-1,3-dioxolane-4-methanol; (4-Hydroxymethyl-2,2,4-trimethyl-1,3-dioxolane); Glycerol 1,2-acetonide; Isopropylidene Glycerol; Solketal; 1,2-O-Isopropylidene Glycerol; 1,2-O-Isopropylideneglycerol; (R/S)-Solketal
EINECS	251-027-5

Quality Control

Our 1,3-Dioxolane-4-Methanol, 2,2,4-Trimethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are kept sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Chiral Purity (Chiral GC/HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.435
Specific Gravity (20°C)	1.060 - 1.080

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.