Description

H-Tbu-Gly-Otbu Hcl is a protected glycine derivative, specifically the hydrochloride salt of N-(tert-Butoxycarbonyl)-glycine tert-butyl ester. This compound is a crucial building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), valued for its role in protecting amine and carboxylic acid functionalities during multi-step organic synthesis. It is primarily utilized by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in advanced organic and medicinal chemistry.

Application

• Peptide Synthesis: Serves as a key protected glycine unit in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides and small molecule drugs.
• Bioconjugation: Acts as a spacer or linker molecule in the preparation of peptide-protein conjugates and other bioconjugates.
• Chemical Biology Research: Employed in the study of peptide structure-activity relationships (SAR) and as a tool compound.
• Fine Chemical Production: An intermediate in the custom synthesis of specialized amino acid derivatives and complex organic molecules.

Basic Information

Product Name	H-Tbu-Gly-Otbu Hcl
CAS No.	31556-74-8
Molecular Formula	C11H22ClNO4
Molecular Weight	267.75 g/mol
Synonyms	N-(tert-Butoxycarbonyl)glycine tert-butyl ester hydrochloride; Boc-Gly-OtBu·HCl; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester, hydrochloride; tert-Butyl N-(tert-butoxycarbonyl)glycinate hydrochloride; Boc-Gly-OC(CH3)3·HCl; (tert-Butoxycarbonyl)glycine tert-butyl ester hydrochloride; Glycine, N-Boc-, O-t-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-Tbu-Gly-Otbu Hcl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.