Description

Methadone Metabolite CAS NO 31161-17-8 is a key intermediate and reference standard derived from the metabolism of the synthetic opioid methadone. This compound is of critical importance for analytical and forensic laboratories requiring precise calibration and validation in drug testing protocols. It is primarily utilized by pharmaceutical R&D facilities, forensic toxicology departments, and contract research organizations (CROs) engaged in pharmacokinetic studies and substance abuse monitoring.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of methadone and its metabolites in biological matrices.
• Forensic Toxicology: Essential for the development, calibration, and quality control of LC-MS/MS, GC-MS, and HPLC methods in workplace drug testing, post-mortem analysis, and DUID (Driving Under the Influence of Drugs) cases.
• Clinical Research: Used in pharmacokinetic and metabolic pathway studies to understand the disposition and clearance of methadone in patients undergoing opioid addiction therapy.
• Method Development & Validation: A critical component for establishing specificity, accuracy, and precision in new analytical methods within regulatory environments (FDA, EMA).
• Quality Control in Manufacturing: Employed as an impurity marker and system suitability standard in the quality assurance of methadone-based pharmaceutical products.
• Academic Research: Supports biochemical and pharmacological research into opioid receptor interactions, metabolic enzymes, and drug-drug interactions.

Basic Information

Product Name	Methadone Metabolite
CAS No.	31161-17-8
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine); 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; Methadone metabolite EDDP; 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; 1,5-Dimethyl-3,3-diphenyl-2-ethylidenepyrrolidine; Pyrrolidine, 2-ethylidene-1,5-dimethyl-3,3-diphenyl-; 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP)
EINECS	Contact for details

Quality Control

Our Methadone Metabolite (EDDP) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and GC-MS, to ensure high purity and identity confirmation suitable for use as a reference standard. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, chromatographic data, and storage recommendations.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.