Description

5-Aminopentane-1-Thiol Hydrochloride is a versatile bifunctional organic building block containing both a primary amine and a thiol group, rendered stable and handleable as its hydrochloride salt. This compound is critical for researchers and manufacturers requiring precise molecular assembly, particularly in the creation of custom linkers, ligands, and functionalized surfaces. It is primarily utilized in pharmaceutical research, material science, and as a key intermediate in the synthesis of more complex chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring thiol- or amine-based conjugation.
• Bioconjugation & Linker Chemistry: Used to create custom cross-linkers and spacers for attaching drugs to antibodies, proteins, or nanoparticles in ADC (Antibody-Drug Conjugate) development and other bioconjugation strategies.
• Peptide Mimetics & Modification: Employed in the design and synthesis of peptide analogs where the thiol and amine functionalities allow for cyclization or side-chain modification.
• Material Science & Surface Functionalization: Acts as a precursor for self-assembled monolayers (SAMs) on gold and other surfaces, enabling the creation of biosensors and tailored material interfaces.
• Ligand Synthesis for Catalysis: Used in the preparation of chelating ligands for metal catalysts, leveraging its dual functionality to bind metal centers.
• Chemical Research & Development: A valuable reagent for exploring novel organic reactions and constructing heterocyclic compounds or small molecule libraries.

Basic Information

Product Name	5-Aminopentane-1-Thiol Hydrochloride
CAS No.	31110-78-8
Molecular Formula	C5H14ClNS
Molecular Weight	155.69 g/mol
Synonyms	5-Amino-1-pentanethiol Hydrochloride; 5-Aminopentyl Mercaptan Hydrochloride; 1-Mercapto-5-aminopentane Hydrochloride; 5-Aminoamyl Mercaptan Hydrochloride; NSC 334365; 5-Aminopentan-1-thiol HCl; 5-Amino-1-pentylthiol Hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Aminopentane-1-Thiol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.