Description

(-)-8,9-Dihydro-8-[1-(Hydroxymethyl)Vinyl]-2H-Furo[2,3-H]-1-Benzopyran-2-One is a high-purity, optically active coumarin derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily sought by research institutions and industrial R&D departments focused on medicinal chemistry, asymmetric synthesis, and the development of new therapeutic compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex molecular architectures.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct stereochemically defined molecules.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies, leveraging its coumarin-based structure.
• Fine Chemical Synthesis: Intermediate for the production of specialized fine chemicals, flavors, and fragrances requiring specific chirality.
• Academic Research: Valuable compound for methodological development in organic synthesis and for training in advanced laboratory techniques.

Basic Information

Product Name	(-)-8,9-Dihydro-8-[1-(Hydroxymethyl)Vinyl]-2H-Furo[2,3-H]-1-Benzopyran-2-One
CAS No.	30625-31-1
Molecular Formula	C14H12O4
Molecular Weight	244.24 g/mol
Synonyms	(-)-8,9-Dihydro-8-(1-hydroxymethylvinyl)-2H-furo[2,3-h]chromen-2-one; (8S)-8,9-Dihydro-8-[(1S)-1-(hydroxymethyl)ethenyl]-2H-furo[2,3-h]-1-benzopyran-2-one; (8S)-8,9-Dihydro-8-[(1S)-1-(hydroxymethyl)vinyl]-2H-furo[2,3-h]chromen-2-one; Furo[2,3-h]chromen-2-one derivative; Optically active dihydrofurocoumarin; Chiral coumarin intermediate
EINECS	Contact for details

Quality Control

Our (-)-8,9-Dihydro-8-[1-(Hydroxymethyl)Vinyl]-2H-Furo[2,3-H]-1-Benzopyran-2-One is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive synthetic applications. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and structural confirmation (NMR, IR, MS). Certificates of Analysis (COA) detailing all specifications are available for every batch upon request, supporting compliance with internal quality standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.