Description

Eschenmoser's Salt is a versatile and highly reactive methylating agent, formally known as (dimethylamino)methylene dimethyliminium chloride. Its primary value lies in its ability to efficiently transfer a methyl group to a variety of nucleophiles under mild conditions, making it a crucial reagent in complex organic synthesis. This compound is particularly sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing key molecular frameworks and advanced intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the methylation of heterocycles, amines, and carboxylic acids in active pharmaceutical ingredient (API) development.
• Agrochemical Production: Used in the synthesis of certain herbicides and pesticides where selective methylation is required.
• Natural Product and Alkaloid Synthesis: Employed in the total synthesis of complex natural products due to its chemoselectivity.
• Material Science Research: Acts as a building block or modifying agent in the development of specialty polymers and functional materials.
• Process Chemistry: Valued for scalable methylation steps in pilot plant and manufacturing processes for fine chemicals.
• Academic & R&D Laboratories: A staple reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	Eschenmoser's Salt
CAS No.	30354-18-8
Molecular Formula	C5H13ClN2
Molecular Weight	136.62 g/mol
Synonyms	(Dimethylamino)methylene dimethyliminium chloride; N,N-Dimethylformamide dimethyl acetal hydrochloride; DMF-DMA hydrochloride; Eschenmoser's reagent; (Dimethylamino)methylenedimethylammonium chloride; N-(Dimethylmethylene)dimethyliminium chloride; 1,1-Dimethyl-2-(dimethylamino)ethyleneiminium chloride
EINECS	250-150-5

Quality Control

Our Eschenmoser's Salt is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	178 - 182 °C
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.