Description

2-Methoxyethoxymethyl Chloride (CAS NO 3970-21-6) is a versatile and reactive alkylating agent primarily used as a key protecting group reagent in complex organic synthesis. Its value lies in its ability to introduce the acid-labile MEM (2-methoxyethoxymethyl) protecting group for alcohols and phenols, offering distinct selectivity advantages in multi-step reaction sequences. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: Employed as a protecting group reagent for hydroxyl functionalities in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of advanced pesticides and herbicides where selective protection of reactive sites is required during synthesis.
• Fine Chemical & Specialty Chemistry: A critical reagent for constructing complex natural products, flavors, fragrances, and performance materials in research and development.
• Peptide & Nucleoside Chemistry: Applied in the protection of sensitive functional groups during the synthesis of oligonucleotides, nucleotides, and modified peptides.
• Polymer Science: Serves as a functional monomer or modifying agent in the development of specialized polymers with tailored properties.
• Academic & Industrial R&D: A staple reagent in laboratory settings for methodological development and exploratory synthesis across organic chemistry.

Basic Information

Product Name	2-Methoxyethoxymethyl Chloride
CAS No.	3970-21-6
Molecular Formula	C4H9ClO2
Molecular Weight	124.57 g/mol
Synonyms	MEM-Chloride; Chloromethyl 2-Methoxyethyl Ether; 2-Methoxyethoxymethyl Chloride; (2-Methoxyethoxy)methyl Chloride; 1-Chloro-2-(2-methoxyethoxy)ethane; NSC 403697; Chloromethoxymethoxyethane; 2-Methoxyethyl Chloromethyl Ether
EINECS	223-600-7

Quality Control

Our 2-Methoxyethoxymethyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.08 - 1.12 g/mL
Refractive Index (n20D)	1.425 - 1.435

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.