Description

1,2:3,4:5,6-Tri-o-Isopropylidene-D-Mannitol is a high-purity, protected derivative of D-mannitol, serving as a crucial chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a rigid, stereochemically defined scaffold that is resistant to side reactions, enabling the precise construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-fidelity intermediates for developing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of nucleoside analogs, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Carbohydrate Chemistry: Serves as a protected starting material for the preparation of complex sugars, glycomimetics, and glycoconjugates.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring specific stereochemistry.
• Agrochemical Research: Acts as an intermediate in developing chiral herbicides, fungicides, and plant growth regulators.
• Academic & R&D: A valuable reagent in university and corporate research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	1,2:3,4:5,6-Tri-o-Isopropylidene-D-Mannitol
CAS No.	3969-59-3
Molecular Formula	C15H26O6
Molecular Weight	302.36 g/mol
Synonyms	1,2:3,4:5,6-Tri-O-isopropylidene-D-mannitol; D-Mannitol 1,2:3,4:5,6-triisopropylidene acetal; 1,2:3,4:5,6-Tri-O-(1-methylethylidene)-D-mannitol; Tri-O-isopropylidene-D-mannitol; D-1,2:3,4:5,6-Di-O-isopropylidene-mannitol; Isopropylidene-D-mannitol; D-Mannitol triacetonide
EINECS	223-574-8

Quality Control

Our 1,2:3,4:5,6-Tri-o-Isopropylidene-D-Mannitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	119 - 123 °C
Specific Rotation [α]20/D	+23.0° to +25.0° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.