Description

7-Bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure makes it a valuable intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its benzoazepinone scaffold.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its heterocyclic structure for bioactivity.
• Organic Synthesis Reagent: Serves as a versatile electrophile or coupling partner in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex molecular fragments.
• Material Science Precursor: Potential intermediate in the synthesis of organic electronic materials or specialty polymers requiring specific brominated aromatic architectures.
• Chemical Biology Probe Development: Used to create tool compounds for studying biological pathways and protein-ligand interactions.

Basic Information

Product Name	7-Bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one
CAS No.	3951-89-1
Molecular Formula	C10H10BrNO
Molecular Weight	240.10 g/mol
Synonyms	7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-one; 7-Bromo-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine; 5H-2,3,4,5-Tetrahydro-1-benzazepin-5-one, 7-bromo-; 7-Bromo-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one; 7-Bromotetrahydrobenzo[b]azepin-5-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.