Description

2-(Chloromethyl)-4(3H)-Quinazolinone is a versatile and high-value heterocyclic building block, primarily recognized for its reactive chloromethyl group fused to a quinazolinone core. This compound matters significantly in advanced organic synthesis, where it serves as a key precursor for constructing more complex molecular architectures. Pharmaceutical research and development teams, as well as agrochemical innovators, need this intermediate for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various pharmacologically active quinazolinone derivatives, which are explored for their anticancer, antimicrobial, and anti-inflammatory properties.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and plant growth regulators, leveraging the bioactive quinazolinone scaffold.
• Material Science Research: Serves as a building block for creating specialty polymers, ligands for metal-organic frameworks (MOFs), or organic electronic materials due to its rigid, planar structure.
• Chemical Biology & Proteomics: Can be utilized to develop activity-based probes or affinity tags for studying enzyme function and protein interactions.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing novel heterocyclic dyes and fluorescent markers.
• Academic & Contract Research: Essential for medicinal chemistry programs and methodological studies in universities and CROs (Contract Research Organizations).

Basic Information

Product Name	2-(Chloromethyl)-4(3H)-Quinazolinone
CAS No.	3817-05-8
Molecular Formula	C9H7ClN2O
Molecular Weight	194.62 g/mol
Synonyms	2-(Chloromethyl)quinazolin-4(3H)-one; 4(3H)-Quinazolinone, 2-(chloromethyl)-; 2-Chloromethyl-4-hydroxyquinazoline; NSC 403714; 2-Chloromethyl-4(3H)-quinazolinone; Quinazolinone, 2-(chloromethyl)-4(3H)-; 2-(Chloromethyl)-4-oxo-3,4-dihydroquinazoline
EINECS	223-300-6

Quality Control

Every batch of 2-(Chloromethyl)-4(3H)-Quinazolinone is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation by atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.