Description

Ethyl 2-(Ethoxymethylene)Acetoacetate is a versatile β-keto ester derivative that serves as a critical building block in organic synthesis. Its unique structure, featuring both an ethoxymethylene and an acetoacetate moiety, makes it a valuable precursor for constructing complex heterocyclic systems and fine chemicals. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediates: A key starting material in the synthesis of quinolone antibiotics, antimalarial drugs, and other nitrogen-containing heterocycles with biological activity.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, contributing to the development of new crop protection agents.
• Fine Chemical Production: Serves as a versatile synthon for creating complex molecules used in dyes, pigments, and functional materials.
• Research & Development: Employed in academic and industrial R&D labs for method development and exploring novel chemical reactions, particularly in cyclocondensation and annulation processes.
• Chemical Synthesis Building Block: Utilized in the preparation of pyrazoles, pyrimidines, and other fused heterocyclic compounds due to its reactive methylene and carbonyl groups.

Basic Information

Product Name	Ethyl 2-(Ethoxymethylene)Acetoacetate
CAS No.	3788-94-1
Molecular Formula	C9H14O4
Molecular Weight	186.21 g/mol
Synonyms	Ethyl (ethoxymethylene)acetoacetate; Ethyl 2-(Ethoxymethylene)-3-oxobutanoate; Acetoacetic acid, 2-(ethoxymethylene)-, ethyl ester; Ethyl α-(ethoxymethylene)acetoacetate; EEAA; 2-(Ethoxymethylene)-3-oxobutanoic acid ethyl ester; Ethyl 3-oxo-2-(ethoxymethylene)butanoate
EINECS	223-265-5

Quality Control

Our Ethyl 2-(Ethoxymethylene)Acetoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for use in advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The container should be kept tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.