Description

2-Nitrophenylacetic Acid is a versatile aromatic nitro acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the reactivity of both the carboxylic acid and the ortho-positioned nitro group, enabling the construction of complex heterocyclic and pharmaceutical intermediates. This compound is essential for R&D chemists and production units in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing indole, quinoline, or other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and plant growth regulators where the nitrophenyl moiety is incorporated into the final molecule.
• Dye and Pigment Manufacturing: Serves as a starting material for azo dyes and other complex colorants, leveraging the nitro group for chromophore development.
• Organic Synthesis Building Block: Employed in coupling reactions, cyclizations, and as a substrate for the reduction of the nitro group to an amine, expanding its utility in peptide mimetics and polymer chemistry.
• Research & Development: A valuable reagent in academic and industrial laboratories for methodological studies and the development of new synthetic pathways.
• Coordination Chemistry: Can act as a ligand or precursor for ligands in metal-organic frameworks (MOFs) and catalysts.

Basic Information

Product Name	2-Nitrophenylacetic Acid
CAS No.	3740-52-1
Molecular Formula	C8H7NO4
Molecular Weight	181.15 g/mol
Synonyms	(2-Nitrophenyl)acetic Acid; 2-Nitrobenzeneacetic Acid; o-Nitrophenylacetic Acid; α-(2-Nitrophenyl)acetic Acid; NSC 403697; 2-Nitrobenzylcarboxylic Acid; (o-Nitrophenyl)ethanoic Acid; 2-Nitrophenylacetic Acid, 98+%
EINECS	223-138-7

Quality Control

Our 2-Nitrophenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	141 - 145 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.