Description

Sieber Linker is a key chemical intermediate widely used in solid-phase peptide synthesis (SPPS) and combinatorial chemistry. Its primary value lies in its role as a versatile and acid-labile linker for anchoring the first amino acid to a resin, enabling the efficient synthesis of complex peptides and peptide libraries. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity building blocks for drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a critical acid-labile linker for anchoring Fmoc-protected amino acids to polymeric resins, facilitating the stepwise assembly of peptide chains.
• Combinatorial Library Generation: Enables the parallel synthesis of diverse peptide libraries for high-throughput screening in drug discovery and lead optimization.
• Synthesis of Modified Peptides: Used in the preparation of peptide conjugates, cyclic peptides, and peptides containing non-natural amino acids or post-translational modifications.
• Research & Development: A fundamental reagent in academic and industrial R&D labs focused on peptide chemistry, medicinal chemistry, and chemical biology.
• Production of Therapeutic Peptides: Employed in the scalable synthesis of peptide-based active pharmaceutical ingredients (APIs) for various therapeutic areas.

Basic Information

Product Name	Sieber Linker
CAS No.	3722-51-8
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	Sieber Amide Resin Linker; 4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic Acid; Fmoc-Sieber Linker; Sieber Linker, Fmoc-protected; 4-[(9H-Fluoren-9-ylmethoxycarbonylamino)(2,4-dimethoxyphenyl)methyl]phenoxyacetic Acid; 4-[Fmoc-amino(2,4-dimethoxyphenyl)methyl]phenoxyacetic Acid; Sieber Amide Linker; 4-(Fmoc-amino-2,4-dimethoxyphenylmethyl)phenoxyacetic Acid
EINECS	Contact for details

Quality Control

Our Sieber Linker is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.