Description

2-[(Diethoxyphosphinothioyl)Thio]Butanedioic Acid Diethyl Ester is a high-purity organophosphorus compound, also known as Malathion Impurity A, serving as a critical intermediate and reference standard. Its primary value lies in ensuring the quality, safety, and regulatory compliance of agrochemical products, particularly in the synthesis and analysis of the insecticide malathion. This compound is essential for manufacturers and analytical laboratories in the agrochemical and pharmaceutical industries who require precise chemical standards for process development, quality control, and impurity profiling.

Application

• Agrochemical Intermediate: A key precursor and impurity reference standard in the synthesis of the organophosphate insecticide Malathion.
• Pharmaceutical Impurity Standard: Used as a certified reference material (CRM) for the identification and quantification of related substances in pharmaceutical active ingredients.
• Analytical Chemistry: Serves as a high-purity standard for method development and validation in chromatographic analysis (HPLC, GC).
• Chemical Research: Employed in academic and industrial R&D for studying organophosphorus chemistry, reaction mechanisms, and degradation pathways.
• Quality Assurance & Control: Critical for establishing impurity profiles and ensuring batch-to-batch consistency in malathion production.
• Regulatory Compliance: Supports compliance documentation for EPA, FDA, and other global regulatory bodies requiring detailed impurity characterization.

Basic Information

Product Name	2-[(Diethoxyphosphinothioyl)Thio]Butanedioic Acid Diethyl Ester
CAS No.	3700-86-5
Molecular Formula	C12H23O6PS2
Molecular Weight	358.41 g/mol
Synonyms	Malathion Impurity A; Diethyl 2-[(dimethoxyphosphinothioyl)thio]succinate (common misnomer); O,O-Diethyl S-[1,2-bis(ethoxycarbonyl)ethyl] phosphorodithioate; Diethyl (dimethoxyphosphinothioyl)thio)butanedioate; Mercaptosuccinic acid diethyl ester, O-ester with O,O-diethyl phosphorodithioate; Succinic acid, mercapto-, diethyl ester, S-ester with O,O-diethyl phosphorodithioate; Phosphorodithioic acid, O,O-diethyl ester, S-ester with diethyl mercaptosuccinate
EINECS	223-031-5

Quality Control

Our 2-[(Diethoxyphosphinothioyl)Thio]Butanedioic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for reference standards in agrochemical and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.