Description

1,2,3-Tribromo-5-Nitrobenzene is a halogenated nitroaromatic compound of significant interest in advanced organic synthesis. Its unique structure, featuring three bromine atoms and a nitro group on a benzene ring, makes it a versatile and valuable building block for creating complex molecules. This intermediate is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries. It enables the synthesis of specialized compounds where precise halogen substitution patterns are critical for biological activity or material properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring specific bromine substitution for targeted drug design.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the nitro and bromine functionalities contribute to product efficacy.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex organic dyes and pigments, leveraging its aromatic nitro-bromo structure for color and stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form new carbon-carbon or carbon-heteroatom bonds.
• Chemical Research & Development: Utilized in academic and industrial R&D labs as a standard or novel reagent for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	1,2,3-Tribromo-5-Nitrobenzene
CAS No.	3460-20-6
Molecular Formula	C6H2Br3NO2
Molecular Weight	359.80 g/mol
Synonyms	1,2,3-Tribromo-5-nitrobenzene; 2,3,4-Tribromonitrobenzene; 5-Nitro-1,2,3-tribromobenzene; NSC 403779; Benzene, 1,2,3-tribromo-5-nitro-; Tribromonitrobenzene (mixed isomers); 1,2,3-Tribromo-5-nitro-benzene
EINECS	Contact for details

Quality Control

Our 1,2,3-Tribromo-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Specifications can be aligned with cGMP or other relevant quality frameworks upon request to support your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and strong bases. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.