Description

Dimethylformamide Hydrogen Chloride Complex is a versatile and highly reactive reagent, primarily serving as a convenient source of hydrogen chloride in organic synthesis. This compound is particularly valued for its controlled acidity and solubility in organic media, enabling precise reactions in moisture-sensitive environments. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, facilitating key transformations such as chlorinations, deprotections, and catalyst preparation.

Application

• Pharmaceutical Synthesis: As a key reagent for the introduction of chlorine atoms, deprotection of amine groups (e.g., Boc, Cbz), and preparation of acid chlorides from carboxylic acids.
• Agrochemical Manufacturing: Used in the synthesis of pesticide and herbicide intermediates requiring chlorination or hydrochloric acid catalysis in non-aqueous systems.
• Polymer & Resin Production: Acts as a catalyst or curing agent in specific polymerization reactions and resin formulations.
• Organic Chemical Research: A preferred HCl source for reactions demanding anhydrous conditions, such as Friedel-Crafts alkylations and rearrangements.
• Catalyst Preparation: Employed in the synthesis and activation of metal catalysts and Lewis acids used in fine chemical production.
• Dye & Pigment Intermediates: Facilitates chlorination and cyclization steps in the synthesis of complex organic colorants.

Basic Information

Product Name	Dimethylformamide Hydrogen Chloride Complex
CAS No.	3397-76-0
Molecular Formula	C3H8ClNO
Molecular Weight	109.55 g/mol
Synonyms	DMF·HCl; N,N-Dimethylformamide Hydrochloride; Dimethylformamide Hydrochloride; Formamide, N,N-dimethyl-, hydrochloride; Hydrogen Chloride-DMF Complex; HCl-DMF Complex; DMF-HCl; DMF Hydrochloride Salt
EINECS	222-248-8

Quality Control

Our Dimethylformamide Hydrogen Chloride Complex is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and identity confirmation, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing purity, physical characteristics, and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (DMF·HCl)	≥ 98.0 %
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.