Description

α-Bromo-4-Chlorophenylacetic Acid is a versatile and high-purity halogenated phenylacetic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive α-bromo moiety adjacent to a carboxylic acid group, enabling efficient carbon-carbon bond formation and functional group interconversions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize complex molecules with precision.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of herbicides and fungicides, leveraging the chlorophenyl moiety for biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating chiral auxiliaries and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: Employed to introduce unnatural amino acid analogs or side-chain functionalities into peptide backbones.
• Material Science Monomer: Can be polymerized or incorporated into polymers to impart specific chemical or physical properties.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or affinity labels to study enzyme function.

Basic Information

Product Name	α-Bromo-4-Chlorophenylacetic Acid
CAS No.	3381-73-5
Molecular Formula	C8H6BrClO2
Molecular Weight	249.49 g/mol
Synonyms	(4-Chlorophenyl)(bromo)acetic acid; 2-Bromo-2-(4-chlorophenyl)acetic acid; 4-Chloro-α-bromophenylacetic acid; p-Chloro-α-bromophenylacetic acid; NSC 403079; Bromo(4-chlorophenyl)acetic acid; α-Bromo-p-chlorophenylacetic acid
EINECS	Contact for details

Quality Control

Every batch of α-Bromo-4-Chlorophenylacetic Acid is manufactured under strict quality management systems. We provide comprehensive quality assurance, with specifications typically meeting or exceeding 98.0% minimum purity (by HPLC). Our products undergo rigorous identity confirmation, purity analysis, and impurity profiling. Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	108°C - 112°C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.