Description

n-tert-Butyl-α-Phenylnitrone (PBN) is a highly effective and well-characterized nitrone spin trap, widely used in electron paramagnetic resonance (EPR) spectroscopy. Its core value lies in its ability to stabilize and detect short-lived free radicals, providing critical insights into oxidative stress mechanisms and reaction pathways. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and material science industries, where understanding radical chemistry is paramount for product development and stability studies.

Application

• Free Radical Research: Primary tool in EPR/spin-trapping experiments to identify and quantify reactive oxygen species (ROS) and other transient radicals.
• Pharmaceutical Development: Used to study oxidative degradation pathways of drug substances and excipients, aiding in formulation stability.
• Biomedical Studies: Investigates the role of free radicals in disease models, such as neurodegeneration, inflammation, and ischemia-reperfusion injury.
• Polymer & Material Science: Monitors radical initiation, propagation, and termination events in polymerization processes and material aging.
• Antioxidant Efficacy Testing: Serves as a standard probe to evaluate the radical-scavenging activity of natural extracts and synthetic antioxidants.
• Food & Cosmetic Science: Applied in research to understand lipid peroxidation and oxidative rancidity, supporting preservation strategy development.

Basic Information

Product Name	n-tert-Butyl-α-Phenylnitrone
CAS No.	3376-24-7
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	PBN; N-tert-Butyl-α-phenylnitrone; α-Phenyl-N-tert-butylnitrone; N-tert-Butyl-α-phenylnitrone; PBN spin trap; Nitrone PBN; 1,1-Dimethylethylphenylnitrone oxide; N-(1,1-Dimethylethyl)-α-phenylnitrone
EINECS	222-168-5

Quality Control

Our n-tert-Butyl-α-Phenylnitrone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	73 - 77 °C
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.