Description

2,2,4,4-Tetramethyltetrahydrofuran is a specialized, high-purity cyclic ether solvent with unique steric and electronic properties. Its value lies in its exceptional stability and solubility profile, making it a critical component for advanced synthesis and formulation processes. This product is essential for research and industrial applications in pharmaceuticals, agrochemicals, and specialty polymers where precise reaction control is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Acts as a versatile solvent and building block in the production of complex active pharmaceutical ingredients (APIs), particularly for reactions requiring anhydrous, non-nucleophilic conditions.
• Agrochemical Formulations: Used as a high-performance solvent and co-solvent in the development of advanced pesticides and herbicides, enhancing the solubility and stability of active ingredients.
• Polymer & Resin Chemistry: Serves as a reaction medium and modifier in the synthesis of specialty polymers, including polyethers and high-performance resins, where its structure influences polymer chain properties.
• Lithium-Ion Battery Electrolytes: Employed as a key component or additive in advanced electrolyte formulations to improve ionic conductivity, stability, and low-temperature performance.
• Laboratory Research & Development: A valuable reagent in organic synthesis for methodologies like Grignard reactions, lithiations, and as a ligand in organometallic chemistry due to its coordinating ability.
• Specialty Coatings & Adhesives: Functions as an effective solvent for high-solids coatings and adhesives, contributing to rapid evaporation rates and final product performance.

Basic Information

Product Name	2,2,4,4-Tetramethyltetrahydrofuran
CAS No.	3358-28-9
Molecular Formula	C8H16O
Molecular Weight	128.21 g/mol
Synonyms	2,2,4,4-Tetramethyloxolane; Tetramethyltetrahydrofuran; TMTHF; Perhydro-2,2,4,4-tetramethylfuran; 2,2,4,4-Tetramethyl-tetrahydro-furan; NSC 66490
EINECS	222-130-8

Quality Control

Our 2,2,4,4-Tetramethyltetrahydrofuran is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flame. Recommended storage temperature is 2-25°C. Due to its highly volatile and easily oxidized nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20/D)	1.408 - 1.412
Density (20°C)	0.815 - 0.825 g/mL
Boiling Point	Approx. 108-110°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.