Description

n-Me-Leu-Ome·Hcl CAS NO 3339-45-5 is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of N-methyl-L-leucine. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering control over stereochemistry and molecular conformation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the N-methylated leucine residue, which can enhance metabolic stability and membrane permeability.
• Biochemical Research: Employed as a standard or reagent in proteomics research and for studying enzyme-substrate interactions involving modified amino acids.
• Prodrug Development: The ester moiety can be utilized in prodrug strategies to improve the bioavailability of peptide drugs.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive molecules.
• Agrochemical Research: Potential application in the synthesis of bioactive peptides for crop protection agents.

Basic Information

Item	Detail
Product Name	n-Me-Leu-Ome·Hcl
CAS No.	3339-45-5
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	N-Methyl-L-leucine methyl ester hydrochloride; Methyl (2S)-2-(methylamino)-4-methylpentanoate hydrochloride; L-Leucine, N-methyl-, methyl ester, hydrochloride; Methyl N-methylleucinate hydrochloride; (S)-Methyl 2-(methylamino)-4-methylpentanoate hydrochloride; N-Me-Leu-OMe·HCl; N-Methylleucine methyl ester HCl
EINECS	Contact for details

Quality Control

Our n-Me-Leu-Ome·Hcl is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.