Description

2-(3-Chloropropyl)-2-(4-Fluorophenyl)-1,3-Dioxolane is a versatile fluorinated and chlorinated dioxolane derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique bifunctional structure, featuring both a reactive chloropropyl arm and a fluorinated aromatic ring, makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, where the fluorine atom can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides, leveraging the fluorophenyl group for improved pesticidal activity and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis or as a component in organometallic complexes.
• Material Science Research: Intermediate for synthesizing monomers or additives aimed at creating polymers with specific optical, electronic, or surface properties.
• Chemical Biology Probes: Serves as a scaffold for developing fluorescent tags or molecular probes used in biochemical and cellular imaging studies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	2-(3-Chloropropyl)-2-(4-Fluorophenyl)-1,3-Dioxolane
CAS No.	3308-94-9
Molecular Formula	C₁₂H₁₄ClFO₂
Molecular Weight	244.69 g/mol
Synonyms	2-(3-Chloropropyl)-2-(p-fluorophenyl)-1,3-dioxolane; 4-Fluoro-α-(3-chloropropyl)benzaldehyde ethylene acetal; 1,3-Dioxolane, 2-(3-chloropropyl)-2-(4-fluorophenyl)-; (4-Fluorophenyl)[2-(3-chloropropyl)-1,3-dioxolan-2-yl]methane; p-Fluorobenzaldehyde (3-chloropropyl) ethylene acetal; 3308-94-9; 2-(4-Fluorophenyl)-2-(3-chloropropyl)-1,3-dioxolane
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Chloropropyl)-2-(4-Fluorophenyl)-1,3-Dioxolane is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure consistent high purity and identity confirmation through advanced techniques like GC, HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.